Alonso, 48, will lead the squad for the rest of the season.
The former Atletico Madrid star has been out of work since standing down as Uruguay’s coach in December following the country’s failure to advance past the group stages of the 2022 World Cup.
This will be Alonso’s first experience coaching in Europe.
His longest coaching tenure was with Pachuca, a Mexican club he led to the Mexican championship in 2016.
Alonso joined Inter Miami before the club’s inaugural season in 2019, but his performance was uneven, and he left by mutual consent in January 2021.
Later that year, he took over as manager of Uruguay’s national team.
Alonso took over a Sevilla club that had won only two of its first eight LaLiga games.
The 2-2 league tie against Rayo Vallecano on Saturday dropped the team to 14th place in the standings, with eight points from a possible 24.
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